The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility
نویسندگان
چکیده
منابع مشابه
The progins progesterone receptor gene polymorphism is not related to endometriosis‐associated infertility or to idiopathic infertility
OBJECTIVE This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors,...
متن کاملPolymorphism of the estrogen receptor β gene is related to infertility and infertility-associated endometriosis.
OBJECTIVE To determine the frequency of the estrogen receptor b gene (ERβ) +1730 G/A polymorphism in infertile women with and without endometriosis and controls. SUBJECTS AND METHODS Case-control study that included 136 women with endometriosis, 69 women without endometriosis and 209 fertile women as controls. The ERβ gene + 1730 G/A polymorphism was identified by RFLP-PCR (Restriction Fragme...
متن کاملThe POLG Gene Polymorphism in Iranian Varicocele-Associated Infertility Patients
Objective(s) Varicocele is associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian varicocele patients. Materials and Methods We determined the POLG CAG repe...
متن کاملThe progesterone receptor PROGINS polymorphism is not related to oxidative stress factors in women with polycystic ovary syndrome
BACKGROUND Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation in progesterone receptor polymorphism with risk of ovarian and breast cancer have concentrated on a variant known as PROGINS. METHODS Ninety-five young women with PCOS and 99 ...
متن کاملAssociation between male infertility and either the +331G/A or the progins polymorphism of the progesterone receptor gene in a Chinese population
BACKGROUND Progesterone has been suggested to contribute to the regulation of spermatogenesis and to facilitate the production of viable sperm. Investigations have showed that polymorphism of progesterone receptor (PGR) is associated with some diseases. OBJECTIVE To analyze the potential relationship between male infertility and the +331G/A and progins polymorphisms of PGR gene. MATERIALS A...
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ژورنال
عنوان ژورنال: Clinics
سال: 2010
ISSN: 1807-5932
DOI: 10.1590/s1807-59322010001100002